Cyclooxygenase-1 isoform maintains the normal lining of the stomach and intestines. This enzyme is present in tissues, including gastrointestinal tract mucosa, kidneys, and platelets. Cyclooxygenase-1 (COX 1) isoform normally produces cytoprotective prostaglandins. This enzyme is constitutively expressed in most tissues. Summary – COX 1 vs COX 2 Inhibitors What are COX 1 Inhibitors?ĬOX 1 inhibitor is a non-steroidal anti-inflammatory drug that inhibits the cyclooxygenase-1 enzyme.
COX 1 vs COX 2 Inhibitors in Tabular FormĦ. Similarities – COX 1 and COX 2 Inhibitorsĥ. COX 1 inhibitor and COX 2 inhibitor are two non-steroidal anti-inflammatory drugs involved in the inhibition of cyclooxygenase 1 (COX 1) and cyclooxygenase 2 (COX 2), respectively. Two isoforms of this enzyme have been identified: COX 1 and COX 2. Non-steroidal anti-inflammatory drugs inhibit a particular rate-limiting enzyme called cyclooxygenase (COX) involved in the production of prostaglandins. They are used in the treatment of a variety of diseases. Non-steroidal anti-inflammatory drugs (NSAIDS) usually provide anti-inflammatory, analgesic, and antipyretic effects. The key difference between COX 1 and COX 2 inhibitors is that COX 1 inhibitor is a non-steroidal anti-inflammatory drug that inhibits cyclooxygenase-1 enzyme expressed constitutively in most tissues while COX 2 inhibitor is a non-steroidal anti-inflammatory drug that inhibits cyclooxygenase-2 enzyme expressed in areas of inflammation.
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